Maternal Milk is more than food:Milk contains bioactive components that shape offspring development.
Milk-derived exosomes are nature’s nanoplatform for intercellular delivery
Milk-derived exosomes (MDEs) are a unique subpopulation of extracellular vesicles abundant in the milk of all mammals. They are 30-150nm in size, has a protective lipid bilayer and adhesive proteins, and originate from the mammary gland epithelial cells. They carry genetic material (long and small non-coding RNAs), proteins, enzymes, and lipids and survive gastrointestinal degradation. The lipid bilayer of exosomes not only increase stability but also increase solubility. MDEs efficiently travel across complex cellular barriers, including the intestinal endothelium and the blood-brain barrier. Thus, MDEs offer superior benefits as a drug delivery platform that surpass the limitations of synthetic liposomes and polymeric nanoparticles. Extensive research efforts are currently underway to utilize MDEs as scalable drug carriers.